Yale Mouse Models

 

Investigator

 

 

Mouse Name

 

Description

 

Publication

Contact

 

Janet L Brandsma

 

HPV Mouse Model

 

A Mouse Model of Human Papilloma Virus-induced Disease

 

J. Virology 69:2716

John.puziss@yale.edu

 

 
Craig M Crews

 

 

MetAP-2

 

Conditional knockout of methionine aminopeptidase-2

 

PNAS USA 103: 10379

John.puziss@yale.edu

 

 
Jack A Elias

 

 

Inducible VEGF

 

Lung-specific expression

 

Nature Med. 10:1095

John.puziss@yale.edu

 

 
Jack A Elias

 

 

Leukemia Inhib Factor

 

Lung-specific expression

 

J. Biol. Chem. 278:31226

John.puziss@yale.edu

 

 
Jack A Elias

 

 

Constitutive IL-10

 

Lung-specific expression

 

J. Biol. Chem. 277:35466

John.puziss@yale.edu

 

 
Jack A Elias

 

 

Inducible IFNgamma 

 

Lung-specific expression

 

J. Exp. Med 192:1587

John.puziss@yale.edu

 

 
Jack A Elias

 

 

Constitutive IL-13

 

Lung-specific expression

 

J. Clin Invest 103:779

John.puziss@yale.edu

 

 
Jack A Elias

 

 

Inducible IL-13

 

Lung-specific expression

 

J Clin Invest 106:1081

John.puziss@yale.edu

 

 
Jack A Elias

 

 

Inducible TGF-beta

 

Lung-specific expression

 

J. Exp. Med 200:377

John.puziss@yale.edu

 

 
Jack A Elias

 

 

Constitutive IL-11

 

Lung-specific expression

 

J. Clin Invest 98:2845

John.puziss@yale.edu

 

 
Jack A Elias

 

 

Inducible IL-11

 

Lung-specific expression

 

J. Clin Invest 100:2501

John.puziss@yale.edu

 

 
Richard A Flavell

 

 

NFAT-Luciferase 

 

 

Hong.peng@yale.edu

 

 
Richard A Flavell

 

 

TLR3 (-/-)

 

Knockout

 

Hong.peng@yale.edu

 

 
 
Richard A Flavell

 

 

 

MKK3 (-/-)

 

 

 

Knockout

 

 

Hong.peng@yale.edu

 

 
Richard A Flavell

 

 

MKK6 (-/-)

 

Knockout

 

Hong.peng@yale.edu

 

 
Richard A Flavell

 

 

JNK 1 (-/-) 

 

Knockout

 

Hong.peng@yale.edu

 

 
Richard A Flavell

 

 

MKK3 (-/-) MKK6 (-/-)

 

Double knockout

 

Hong.peng@yale.edu

 

 
Richard A Flavell

 

 

IRAK-M (-/-)

 

Knockout

 

Hong.peng@yale.edu

 

 
Richard A Flavell

 

 

TIRAP (-/-)

 

Knockout

 

Hong.peng@yale.edu

 

 
Richard A Flavell

 

 

RIP2 (-/-)

 

Knockout

 

Hong.peng@yale.edu

 

 
Richard A Flavell

 

 

TLR5 (-/-)

 

Knockout

 

Hong.peng@yale.edu

 

 
Richard A Flavell

 

 

AP1-Luciferase

 

 

Hong.peng@yale.edu

 

 
Richard A Flavell

 

 

RIP.B7/DQ8/MHC Class II 

 

Knockout

 

Hong.peng@yale.edu

 

 
Richard A Flavell

 

 

JNK 2 (-/-)

 

Knockout

 

Hong.peng@yale.edu

 

 
Richard A Flavell

 

 

Kv1.3 

 

Knockout

 

Hong.peng@yale.edu

 

 
Richard A Flavell

 

 

Nod2

 

Knockout

 

Hong.peng@yale.edu

 

Richard A Flavell
 

foxp3-RFP (FIR)

 

Knock-in

 

Hong.peng@yale.edu

 

 

 
Richard A Flavell

 

 

Tie-2 Cre recombinase

 

Transgenic; used to create conditional vcam-1 deficient mice 

 

Hong.peng@yale.edu

 

 
Richard A Flavell

 

 

TLR1 (-/-)

 

Knockout

 

Hong.peng@yale.edu

 

 
Richard A Flavell

 

 

TLR5 (-/-)

 

Knockout

 

Hong.peng@yale.edu

 

 
Richard A Flavell

 

 

TGF-beta GFP KI

 

Knock-in

 

Hong.peng@yale.edu

 

 
Richard A Flavell

 

 

eGFP-IL10 

 

Knock-in

 

Hong.peng@yale.edu

 

 

Wang Min

 

CCM3(PDCD10)

 

Knockout

 

John.puziss@yale.edu

 

 

Marina Picciotto

 

TetOp-beta2 transgenic

 

Inducible transgene for the beta2 subunit of nicotinic acetylcholine receptor

 

J Neuroscience 23: 3837

John.puziss@yale.edu

 

 

Marina Picciotto

 

nestin-tTA transgenic

 

Nestin promoter driving tetracycline transactivator 3 3

J Comp Neurol 475:128

John.puziss@yale.edu

 

 

Marina Picciotto

 

CaM kinase I alpha KO

 

alpha isoform of calcium/calmodulin dependent kinase I (early lethal)

 

John.puziss@yale.edu

 

 

Shlomchik

 

AM14

 

Produce Rheumatoid Factor; Develop autoimmunity in predictable manner

 

Immunity 19:837

David.lewin@yale.edu

 

 

Shlomchik

 

CD20

 

Deplete B cells in lupus-prone mouse model via expression of human CD20

 

David.lewin@yale.edu

 

 

Shlomchik

 

VH186.2

 

 

Immunity 19:837

David.lewin@yale.edu

 

 

Shlomchik

 

VH186.2L

 

 

Immunity 19:837

David.lewin@yale.edu

 

 

Wei, Ning

 

Csn2 (+/-)

 

lacZ insertion; Csn2+/- genotype has no phenotype

 

Mol Cell Biol. 23:6790

John.puziss@yale.edu

 

 

Zhang, Hui

 

SKP2

 

Prostate cancer model (Prostate-specific SKP2 expression) 

 

Canc. Res 63:1583

John.puziss@yale.edu