Recent publications (full list on PubMed)
Identification of specificity determining residues in peptide recognition domains using an information theoretic approach applied to large-scale binding maps
Yip, K. Y., Utz, L., Sitwell, S., Hu, X., Sidhu, S. S., Turk, B. E., Gerstein, M. B., Kim, P. M.
BMC Biol. 9, 53 (2011)
Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-Homologous Kinase (CHK) and Identification of β-synuclein as a potential CHK physiological substrate
Ia, K. K., Jeschke, G. R., Deng, Y., Kamaruddin, M. A., Williamson, N. A., Scanlon, D. B., Culvenor, J. G., Hossain, M. I., Purcell, A. W., Liu, S., Zhu, H. J., Catimel, B. L., Turk, B. E., Cheng, H. C.
Biochemistry 50, 6667-6677 (2011)
Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation
Kikani, C. K., Antonysamy, S. A., Bonanno, J. B., Romero, R., Zhang, F. F., Russell, M., Gheyi, T., Iizuka, M., Emtage, S., Sauder, J. M., Turk, B. E., Burley, S. K., and Rutter, J.
J. Biol. Chem. 285, 41034-41043 (2010)
The Arabidopsis ABA-activated kinase OST1 phosphorylates the bZIP transcription factor ABF3 and creates a 14-3-3 binding site involved in its turnover
Sirichandra, C., Davanture, M., Turk, B. E., Zivy, M., Valot, B., Leung, J., and Merlot, S.
PLoS One 5, e13935 (2010)
Phosphorylation of immunity-related GTPases by a parasite secretory kinase promotes macrophage survival and virulence
Fentress, S. J., Behnke, M. S., Dunay, I. R., Mashayekhi, M., Rommereim, L. M., Fox, B. A., Bzik, D. J., Taylor, G. A., Turk, B. E., Lichti, C. F., Townsend, R. R., Qiu, W., Hui, R., Beatty, W. L. and Sibley, L. D.
Cell Host Microbe 8, 484-495 (2010)
MOTIPS: Automated motif analysis for predicting targets of modular protein domains
Lam, H. Y. K., Kim, P. M., Mok, J., Tonikian, R., Sidhu, S. S., Turk, B. E., Snyder, M., and Gerstein, M. B.
BMC Bioinformatics 11, 243 (2010)
Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs
Mok, J., Kim, P. M., Lam, H. Y. K., Piccirillo, S., Zhou, X., Jeschke, G. R., Sheridan, D. L., Parker, S. A., Desai, V., Jwa, M., Cameroni, E., Niu, H., Good, M., Remenyi, A., Ma, J. N., Sheu, Y., Sassi, H. E., Sopko, R., Chan, C. S. M., De Virgilio, C., Hollingsworth, N. M., Lim, W. A., Stern, D. F., Stillman, B., Andrews, B. J., Gerstein, M. B., Snyder, M. and Turk, B. E.
Sci. Signal., 3, ra12 (2010)
Analysis of protein kinase specificity using arrayed positional scanning peptide libraries
Chen, C. and Turk, B. E.
Curr. Protoc. Mol. Biol. Unit 18.14 (2010)
Active site determinants of substrate recognition by the metalloproteinases TACE and ADAM10
Caescu, C. I., Jeschke, G. R. and Turk, B. E.
Biochem. J., 424, 79-88 (2009)
Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases
Davis, T. L., Walker, J. R., Allali-Hassani, A., Parker, S. A., Turk, B. E., and Dhe-Paganon, S.
FEBS J., 276, 4395-4404 (2009)
Mixture-based peptide libraries for identifying protease cleavage motifs
Turk, B. E.
Meth. Mol. Biol. 539, 79-91 (2009)
Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation
Bullock, A. N., Das, S., Debreczeni, J. E., Rellos, P., Fedorov, O., Niesen, F., Guo, K., Papagrigoriou, E., Amos, A. L., Cho, S., Turk B. E., Ghosh, G. and Knapp, S.
Structure 17, 352-362 (2009)
Structural insights into the inhibited states of the Mer receptor tyrosine kinase
Huang, X., Finerty, P., Walker, J. R., Butler-Cole, C., Vedadi, M., Shapira, M., Parker, S. A., Turk, B. E., Thompson, D. A., and Dhe-Paganon, S.
J. Struct. Biol. 165, 88-96 (2009)
Structural coupling of Fes and Abl SH2-kinase domains links substrate recognition and kinase activation
Filippakopoulos, P., Kofler, M., Hantschel, O., Gish, G. D., Grebien, F., Salah, E., Neudecker, P., Kay, L. E., Turk, B. E., Pawson, T. and Knapp, S.
Cell 134, 793-803 (2008)
Linear motif atlas for phosphorylation-dependent signaling
Miller, M. L., Jensen, L. J., Diella, F., Jørgensen, C., Tinti, M., Li, L., Hsiung, M., Parker, S. A., Bordeaux, J., Sicheritz-Ponten, T., Knapp, S., Blom, N., Bork, P., Li, S., Cesareni, G., Pawson, T., Turk, B. E., Yaffe, M. B., Brunak, S. and Linding, R.
Sci. Signal., 1, ra2 (2008)
Substrate discrimination among mitogen-activated protein kinases through distinct docking sequence motifs
Sheridan, D. L., Kong, Y., Parker, S. A., Dalby, K. N., and Turk, B. E.
J. Biol. Chem. 283, 19511-19520 (2008)
AMPK phosphorylation of raptor mediates a metabolic checkpoint
Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk B. E. and Shaw, R. J.
Mol. Cell. 30, 214-226 (2008)
Understanding and exploiting substrate recognition by protein kinases
Turk, B. E.
Curr. Opin. Chem. Biol. 12, 4-10 (2008)
Structure of the human protein kinase MPSK1 reveals a novel activation loop architecture
Eswaran, J., Bernad, A., Ligos, J. M., Guinea, B., Debreczeni, J. E., Sobott, F., Parker, S. A., Najmanovich, R., Turk, B. E. and Knapp, S.
Structure 16, 115-124 (2008)
Activation segment dimerization: a mechanism for kinase auto-phosphorylation of non-consensus sites
Pike, A. W., Rellos, P., Nielsen, F. H., Turnbull, A., Oliver, A. W., Parker, S. A., Turk, B. E., Pearl, L. H. and Knapp, S.
EMBO J. 27, 704-714 (2008)
Discovery and development of anthrax lethal factor metalloproteinase inhibitors
Turk, B. E.
Curr. Pharm. Biotechnol. 9, 24-33 (2008)
Specificity profiling of Pak kinases allows identification of novel phosphorylation sites
Rennefahrt, U. E. E., Deacon, S., Parker, S. A., Devarajan, K., Beeser, A., Chernoff, J., Knapp, S., Turk, B. E., and Peterson, J. R.
J. Biol. Chem. 282, 15667-15678 (2007)
Manipulation of host signaling pathways by anthrax toxins
Turk, B.E.
Biochem. J. 402, 405-417 (2007)
Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase
Fu, Z., Larson, K.A., Chitta, R.K., Parker, S.A., Turk, B.E., Lawrence, M.W., Kaldis, P., Galaktionov, K., Cohn, S.M., Shabanowitz, J., Hunt, D.F. and Sturgill, T.W.
Mol. Cell. Biol. 26, 8639-8654 (2006)
Determining protein kinase substrate specificity by parallel solution-phase assay of large numbers of peptide substrates
Turk, B.E., Hutti, J.E. and Cantley, L.C.
Nat. Protocols 1, 375-379 (2006)
Structure and substrate specificity of the Pim-1 kinase
Bullock, A.N., Debreczeni, J., Knapp, S. and Turk, B.E.
J. Biol. Chem. 280, 41675-41682 (2005)
Measuring kinase activity: finding needles in a haystack
Turk, B.E.
Nat. Methods 2, 251-252 (2005)
A rapid method for determining protein kinase phosphorylation specificity
Hutti, J.E., Jarrell, E.T., Chang, J.D., Abbott, D.W., Storz, P., Toker, A., Cantley, L.C. and Turk, B.E.
Nat. Methods 1, 27-29 (2004)
The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor
Turk, B.E., Wong, T.Y., Schwarzenbacher, R., Jarrell, E.T., Leppla, S.H., Collier, R.J., Liddington R.C. and Cantley, L.C.
Nat. Struct. Mol. Biol. 11, 60-66 (2004).
Identification of small molecule inhibitors of anthrax lethal factor
Panchal, R.G., Hermone, A.R., Nguyen, T.L., Wong, T.Y., Schmidt, J., Lane, D., Millard, C., McGrath, C., Turk, B.E., Burnett, J., Aman, J., Carra, J., Little, S., Sausville, E.A., Zaharevitz, D.W., Cantley, L.C., Liddington, R.C., Gussio, R. and Bavari, S.
Nat. Struct. Mol. Biol. 11, 67-72 (2004)
Using peptide libraries to identify optimal cleavage motifs for proteolytic enzymes
Turk, B.E. and Cantley, L.C.
Methods 32, 398-405 (2004)
Peptide libraries: at the crossroads of bioinformatics and proteomics
Turk, B.E. and Cantley, L.C.
Curr. Opin. Chem. Biol. 7, 84-90 (2003)
Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi
Martins, L.M., Turk, B.E., Cowling, V., Borg, A., Jarrell, E.T., Cantley, L.C. and Downward, J.
J. Biol. Chem. 278, 49417-49427 (2003)
Determination of protease cleavage site motifs using mixture-based oriented peptide libraries
Turk, B.E., Huang, L.L., Piro, E.T. and Cantley, L.C.
Nat. Biotechnol. 19, 661-667 (2001)
