Section of Infectious Diseases

• Michael Cappello MD, Associate Professor
  Academic Interests: Molecular Parasitology Adoption Medicine

Non-Faculty members (clerical, nursing, admin, etc.)

• Lisa Harrison MS, Research Associate

Post-doctoral fellows, post-doctoral research associates, and other trainees

• Richard Bungiro PhD, Post-doc fellow, Brown Univ.
• Julius Mieszczanek PhD, Post-doc fellow, Warsaw Agricultural University
• Brian Jones PhD, Post-doc fellow, Yale University
• Melissa Held MD, Post-doc fellow, Cornell Univ
• Angela Shih MPH, thesis student, Yale Univ.

Current Grant Support

Name	Title	Funding Agency	Dates
Research grant (R01)	Molecular pathogenesis of hookworm anemia	NIH/NIAID	4/01/02-3/30/06
Research grant	Secretory protease inhibitors from adult Ancyolostoma ceylanicum	March of Dimes	7/1/01-6/30/04
Grant-in-Aid	A novel platelet inhibitor from bloodfeeding hookworms	American Heart Association	7/1/02-6/30/05

Honors and Awards for 2001 and 2002

• New England Association of Parasitologists, Elected President (2001-03)

Publications for 2001 and 2002:

Original reports:
Bungiro RD, Greene J, Kruglov E, Cappello M. Mitigation of hookworm disease following immunization with soluble extracts of Ancylostoma ceylanicum. J Infect Dis 2001;183:1380-7

Bungiro RD, Harrison LM, Cappello M. Ancylostoma ceylanicum Excretory/Secretory Protein 1: Purification and molecular cloning of a major secretory protein from adult hookworms. Mol Biochem Parasitol 2002;119:147-51

Duarte J, Harrison LM, Cappello M. Ancylostoma ceylanicum: Exsheathment is not required for successful cryopreservation of third stage hookworm larvae. Am J Trop Med Hyg (in press).

Harrison LM, Cordova JL, Cappello M. Ancylostoma caninum Anticoagulant Peptide-5: Immunolocalization and in vitro neutralization of a major hookworm anti-thrombotic. Mol Biochem Parasitol 2001;115:101–7

Harrison LM, Nerlinger A, Bungiro RD, Cordova J, Kuzmic P, Cappello M. Molecular characterization of Ancylostoma inhibitors of coagulation factor Xa: hookworm anticoagulant activity in vitro predicts parasite bloodfeeding in vivo. J Biol Chem 2002;277:6223-9

Narasimhan S, Koski R, Beaulieu B, Anderson JF, Ramamoorthi N, Kantor F, Cappello M, Fikrig E. A novel family of anticoagulants from the saliva of Ixodes scapularis. Insect Mol Biol 2002;11:641-50

Reviews and Chapters:
Cappello M. Acute Myocarditis. In: Jenson HB and Baltimore RS, Eds. Pediatric Infectious Diseases: Principles and Practice. Second Edition. Stamford, CT: Appleton & Lange, 2001

Cappello M. Acute Pericarditis. In: Jenson HB and Baltimore RS, Eds. Pediatric Infectious Diseases: Principles and Practice. Second Edition. Stamford, CT: Appleton & Lange, 2001

Cappello M. Cysticercosis. In: Burg FD, Ingelfinger JR, Polin RA, Gershon A, eds. Gellis & Kagan's Current Pediatric Therapy 17. Philadelphia, PA: WB Saunders, 2002

Cappello M. Trichinosis. In: Burg FD, Ingelfinger JR, Polin RA, Gershon A, eds. Gellis & Kagan's Current Pediatric Therapy 17. Philadelphia, PA: WB Saunders, 2002

Cappello M, Barry M. Cestodes. In: Blaser MJ, Smith PD, Ravdin JI, Greenberg HB, Guerrant RL, eds. Infections of the Gastrointestinal Tract. Second Edition. New York: Raven Press, Ltd. 2002

Cappello, M. Hookworm Infection. In: Rudolph AM, Rudolph CD, Siegel NJ, Lister G, Hostetter MK, Eds. Rudolph's Pediatrics. Stamford, CT: Appleton & Lange, 2002

Cappello M. Pediatric Travel Medicine. In: Rudolph AM, Rudolph CD, Siegel NJ, Lister G, Hostetter MK, Eds. Rudolph's Pediatrics. Stamford, CT: Appleton & Lange, 2002

Cappello M. Antiparasitic Drug Therapy. In: Rudolph AM, Rudolph CD, Siegel NJ, Lister G, Hostetter MK, Eds. Rudolph's Pediatrics. Stamford, CT: Appleton & Lange, 2002

Cappello M, Hotez PJ. Intestinal Nematodes. In: Long SS, Pickering LK, Prober CG, Eds. Principles and Practice of Pediatric Infectious Diseases. Second Edition. New York: Churchill Livingstone 2002

Cappello M, Harrison LM, Bungiro RD, Chadderdon CR, Del Valle A, Milstone AM, Chu D, Mieszczanek J, Nerlinger A, Kuzmic P. Molecular pathogenesis of hookworm anemia: prospects for a disease based vaccine. J Parasitol (invited review) (in press).

Del Valle A, Cappello M. Ascaris lumbricoides. In: Burg FD, Ingelfinger JR, Polin RA, Gershon A, eds. Gellis & Kagan's Current Pediatric Therapy 17. Philadelphia, PA: WB Saunders, 2002

Del Valle A, Cappello M. Enterobius vermicularis (Pinworm). In: Burg FD, Ingelfinger JR, Polin RA, Gershon A, eds. Gellis & Kagan's Current Pediatric Therapy 17. Philadelphia, PA: WB Saunders, 2002

Milstone LM, Cappello M, Hotez PJ. What does hookworm invasion tell us about the epidermal barrier and emerging diseases of the skin? In: Klaus, S and Hamburger, J, Eds. Skin: The Barrier Zone, 2001

Research Interests
Dr. Michael Cappello is a member of the Infectious Diseases Section of Yale Pediatrics. Dr. Cappello's laboratory is trying to understand how parasitic infections impact maternal and child health. In addition, he has isolated novel proteins from parasites that may have potential use in the treatment of cardiovascular disorders and cancer.